Unlocking drug modes of action with multi-dimensional high-throughput metabolic profiling

Nature Biotechnology, Published online: 28 January 2025; doi:10.1038/s41587-024-02525-4

Large-scale profiling of drug-induced metabolic changes have potential for improving drug development but remain challenging. We created a computational and experimental large-scale metabolic profiling framework that enabled us to map metabolic effects for 1,520 diverse drugs. This platform revealed new modes of action and potential therapeutic uses for already market-approved drugs.